{"id":417,"date":"2025-10-26T10:06:55","date_gmt":"2025-10-26T08:06:55","guid":{"rendered":"https:\/\/tempull.com\/?p=417"},"modified":"2026-07-25T23:34:35","modified_gmt":"2026-07-25T21:34:35","slug":"kanceri-i-pankreasit-zakoni-i-rrezikshem-qe-shkakton-formen-agresive-te-semundjes","status":"publish","type":"post","link":"https:\/\/tempull.com\/index.php\/2025\/10\/26\/kanceri-i-pankreasit-zakoni-i-rrezikshem-qe-shkakton-formen-agresive-te-semundjes\/","title":{"rendered":"Kanceri i pankreasit, zakoni i rreziksh\u00ebm q\u00eb \u201cshkakton\u201d form\u00ebn agresive t\u00eb s\u00ebmundjes"},"content":{"rendered":"

Kanceri i pankreasit \u00ebsht\u00eb nj\u00eb nga format m\u00eb agresive t\u00eb s\u00ebmundjes, me mund\u00ebsi t\u00eb kufizuara trajtimi dhe shkall\u00eb t\u00eb lart\u00eb vdekshm\u00ebrie.<\/p>\n

Hulumtimet e fundit sugjerojn\u00eb se pirja e duhanit \u00ebsht\u00eb nj\u00eb faktor i r\u00ebnd\u00ebsish\u00ebm rreziku, por mekanizmat e sakt\u00eb mbeten t\u00eb paqarta.<\/p>\n

Nj\u00eb studim i ri hedh drit\u00eb mbi m\u00ebnyr\u00ebn se si toksinat e duhanit ndikojn\u00eb n\u00eb sistemin imunitar dhe p\u00ebrshpejtojn\u00eb rritjen e tumorit.<\/p>\n

N\u00eb m\u00ebnyr\u00eb specifike, hulumtimi shpjegon pse duhanpir\u00ebsit kan\u00eb m\u00eb shum\u00eb gjasa t\u00eb zhvillojn\u00eb kancer pankreatik dhe pse ata kan\u00eb rezultate m\u00eb t\u00eb k\u00ebqija krahasuar me jo-duhanpir\u00ebsit.<\/p>\n

Studiuesit nga Qendra e Kancerit Rogel e Universitetit t\u00eb Mi\u00e7iganit gjat\u00eb studimit, t\u00eb botuar n\u00eb Cancer Discovery, identifikuan nj\u00eb lloj qelize specifike q\u00eb i p\u00ebrgjigjet toksinave mjedisore, t\u00eb tilla si ato q\u00eb p\u00ebrmbahen n\u00eb cigare.<\/p>\n

Kur toksinat lidhen me k\u00ebto qeliza, ato shkaktojn\u00eb lirimin e nj\u00eb proteine, interleukin-22 (IL-22), e cila \u00e7on n\u00eb rritje agresive t\u00eb tumorit tek minjt\u00eb me kancer pankreatik.<\/p>\n

Analiza e m\u00ebtejshme zbuloi nj\u00eb lloj qelize imune hiper-shtyp\u00ebse q\u00eb e rrit k\u00ebt\u00eb p\u00ebrgjigje, nd\u00ebrsa nj\u00ebkoh\u00ebsisht parandalon sistemin imunitar t\u00eb luftoj\u00eb rritjen e tumorit.<\/p>\n

Studiuesit filluan duke administruar nj\u00eb kimikat t\u00eb gjetur n\u00eb cigare dhe toksina t\u00eb tjera mjedisore te minjt\u00eb me tumore pankreatike p\u00ebr t\u00eb studiuar efektin e tij n\u00eb IL-22.<\/p>\n

Hulumtimet e m\u00ebparshme kan\u00eb treguar se IL-22 luan nj\u00eb rol n\u00eb mikroambientin e tumoreve pankreatike.<\/p>\n

Nj\u00eb receptor i specializuar q\u00eb gjendet n\u00eb qelizat q\u00eb prodhojn\u00eb IL-22 lidhet me kimikate, jo me proteinat natyrale t\u00eb vet\u00eb trupit, duke e b\u00ebr\u00eb at\u00eb nj\u00eb hap t\u00eb par\u00eb logjik p\u00ebr t\u00eb shqyrtuar efektin e kancerogjenit n\u00eb IL-22.<\/p>\n

\u201cNdryshon n\u00eb m\u00ebnyr\u00eb dramatike sjelljen e tumoreve. Ato rriten ndjesh\u00ebm, metastazohen n\u00eb t\u00eb gjith\u00eb trupin. Ishte v\u00ebrtet mbres\u00ebl\u00ebn\u00ebse\u201d<\/em>, tha Dr. Timothy L. Frankel. Ekipi m\u00eb pas hetoi mekanizmin q\u00eb \u00e7oi n\u00eb k\u00ebt\u00eb rritje t\u00eb p\u00ebrshpejtuar t\u00eb tumorit. Ata konfirmuan se te minjt\u00eb pa sistem imunitar, toksinat kimike nuk shkaktuan rritje t\u00eb tumorit, duke treguar se kancerogjeni vepron p\u00ebrmes sistemit imunitar.<\/p>\n

M\u00eb pas, ata zbuluan se IL-22 kontribuon n\u00eb prodhimin e qelizave T-rregulluese, nj\u00eb lloj qelize q\u00eb shoq\u00ebrohet me \u00e7rregullime autoimune, por q\u00eb m\u00eb par\u00eb nuk ishte shoq\u00ebruar me kancerin e pankreasit.<\/p>\n

\u201cK\u00ebto qeliza rregulluese T mund t\u00eb prodhojn\u00eb IL-22 dhe t\u00eb shtypin fuqish\u00ebm \u00e7do p\u00ebrgjigje imune. \u00cbsht\u00eb nj\u00eb goditje e dyfisht\u00eb. Kur hoq\u00ebm t\u00eb gjitha qelizat T-reg nga minjt\u00eb, aft\u00ebsia e kimikatit t\u00eb cigareve p\u00ebr t\u00eb lejuar rritjen e tumorit u p\u00ebrmbys plot\u00ebsisht\u201d,<\/em>\u00a0shpjegoi Frankel.<\/p>\n

Rezultatet u konfirmuan n\u00eb qelizat imune njer\u00ebzore, si dhe n\u00eb qelizat e pacient\u00ebve me kancer pankreatik. N\u00eb fakt, duhanpir\u00ebsit me kancer pankreatik kishin m\u00eb shum\u00eb qeliza T-reg sesa jo-duhanpir\u00ebsit.<\/p>\n

P\u00ebrve\u00e7 k\u00ebsaj, studiuesit treguan se nj\u00eb frenues q\u00eb bllokon veprimin e kimikatit t\u00eb cigareve ishte efektiv n\u00eb tkurrjen e tumoreve.<\/p>\n

Megjithat\u00eb, shkenc\u00ebtar\u00ebt v\u00ebrejn\u00eb se nevojiten k\u00ebrkime t\u00eb m\u00ebtejshme p\u00ebr t\u00eb vler\u00ebsuar potencialin e nj\u00eb ila\u00e7i q\u00eb pengon k\u00ebt\u00eb toksin\u00eb mjedisore ose bllokon k\u00ebt\u00eb rrug\u00eb sinjalizimi. P\u00ebr m\u00eb tep\u00ebr, rezultatet sugjerojn\u00eb nevoj\u00ebn p\u00ebr trajtim t\u00eb personalizuar bazuar n\u00eb ekspozimin e pacient\u00ebve ndaj tymit t\u00eb cigares.<\/p>\n

\u201cNj\u00eb qasje e ndryshme mund t\u00eb jet\u00eb e nevojshme p\u00ebr t\u00eb trajtuar duhanpir\u00ebsit q\u00eb zhvillojn\u00eb kancer pankreatik\u201d,<\/em>\u00a0tha Frankel, duke shtuar se\u00a0\u201cnuk ka nj\u00eb metod\u00eb t\u00eb besueshme shqyrtimi, por duhanpir\u00ebsit duhet t\u00eb informohen p\u00ebr simptomat dhe t\u00eb marrin n\u00eb konsiderat\u00eb referimin n\u00eb nj\u00eb klinik\u00eb me rrezik t\u00eb lart\u00eb\u201d.<\/em><\/p>\n

Ai k\u00ebshillon q\u00eb njer\u00ebzit me nj\u00eb histori familjare t\u00eb kancerit t\u00eb pankreasit ose s\u00ebmundjeve t\u00eb tjera inflamatore t\u00eb pankreasit duhet t\u00eb shmangin pirjen e duhanit.<\/p>\n

Ky studim ofron njohuri kritike mbi rolin e pirjes s\u00eb duhanit n\u00eb kancerin e pankreasit, duke treguar se toksinat e duhanit jo vet\u00ebm q\u00eb nxisin rritjen e tumorit, por edhe shtypin p\u00ebrgjigjen imunitare anti-tumorale p\u00ebrmes qelizave T-rregulluese. Zbulimi hap rrug\u00ebn p\u00ebr agjent\u00eb t\u00eb rinj farmaceutik\u00eb dhe strategji t\u00eb personalizuara parandaluese dhe trajtimi p\u00ebr duhanpir\u00ebsit dhe pacient\u00ebt me risk t\u00eb lart\u00eb.<\/p>\n

Lexo edhe:<\/p>\n

Rrezik p\u00ebr sh\u00ebndetin, AKU bllokon \u00e7okokrem me salmonel\u00eb<\/a><\/p>\n

Qum\u00ebsht me kimikate\/ Arben Ndreka i Lufr\u00ebs, krime kund\u00ebr sh\u00ebndetit, p\u00ebrfitoi 800 mij\u00eb \u20ac nga fondet e BE<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Kanceri i pankreasit \u00ebsht\u00eb nj\u00eb nga format m\u00eb agresive t\u00eb s\u00ebmundjes, me mund\u00ebsi t\u00eb kufizuara trajtimi dhe shkall\u00eb t\u00eb lart\u00eb vdekshm\u00ebrie. Hulumtimet e fundit sugjerojn\u00eb se pirja e duhanit \u00ebsht\u00eb nj\u00eb faktor i r\u00ebnd\u00ebsish\u00ebm rreziku, por mekanizmat e sakt\u00eb mbeten t\u00eb paqarta. Nj\u00eb studim i ri hedh drit\u00eb mbi m\u00ebnyr\u00ebn se si toksinat e duhanit […]<\/p>\n","protected":false},"author":1,"featured_media":418,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","footnotes":""},"categories":[26],"tags":[],"class_list":["post-417","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sociale"],"yoast_head":"\nKanceri i pankreasit, zakoni i rreziksh\u00ebm q\u00eb \u201cshkakton\u201d form\u00ebn agresive t\u00eb s\u00ebmundjes - TEMPULL<\/title>\n<meta name=\"description\" content=\"Kanceri i pankreasit \u00ebsht\u00eb nj\u00eb nga format m\u00eb agresive t\u00eb s\u00ebmundjes, me mund\u00ebsi t\u00eb kufizuara trajtimi dhe shkall\u00eb t\u00eb lart\u00eb vdekshm\u00ebrie.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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